Heart Congress

Rano Alieva

Republican Specialized Scientific and Practical Medical Center of Cardiology

Abstract Title:Comparison of patients with ischemic heart disease with and without a history of major cardiovascular events.

Biography:

Alieva Rano has completed her PhD at the age of 45 years at the Department of Ischemic Heart Disease and Atherosclerosis. Explores the incidence of atherosclerosis in Uzbekistan, in-depth studies the familial forms of dyslipidemia, in particular its heterozygous and homozygous forms.

Research Interest:

Republican Specialized Scientific and Practical Medical Center of Cardiology of the Ministry of Health of the Republic of Uzbekistan” Tashkent, Uzbekistan

Introduction:Cardiovascular diseases (CVD) continue to occupy a leading place in the structure of mortality and disability of the population in most economically developed countries of the world. Prevention of adverse outcomes is the most important goal of treatment of patients with stable ischemic heart disease (IHD), no less significant than a positive effect on the manifestations of ischemia. Since the beginning of the twentieth century, acute myocardial infarction and stroke have been considered and remain to this day the leading causes of death of patients worldwide. Arterial hypertension, dyslipidemia, obesity, diabetes mellitus, chronic inflammation remain some of the most important risk factors for the development of CHD, as well as the development of cardiovascular outcomes. In this regard, the aim of the study was to evaluate the markers of coronary heart disease in patients with and without MACE (Major adverse cardiovascular events).

Materials and methods: The study included 109 pts with an established diagnosis of CHD, hospitalized in the RSSPMCC due to destabilization or the need for revascularization. The patients were given anamnesis on the presence of MACE and divided into 2 groups with and without MACE. In this case, laboratory and instrumental data of the study were carried out with their subsequent interpretation and comparison of the groups.

Results: The 2 groups were comparable with each other and did not differ in age 59 ± 8.0 and 61 ± 2.0 years, respectively, for the MACE group and without. And the gender distribution was approximately equal 59.4% men and 41.6% women for the first group, and 57.7% men and 42.3% women, respectively. When evaluating laboratory data, a lower level of HDL-C was noted in patients with PCI (percutaneous interventions) (46±7 dg/ml and 40.00 dg/ml, p<0.005). However, when evaluating patients with a history of CABG, an increased waist circumference (WC) was noted 104±4.1 cm versus 99±5.2 cm in patients without CABG, p<0.005. Elevated lipid profile was noted in patients without CABG TC 225±27 mg/dl and 197±21 dg/ml, p<0.001, LDL-C 142±24 dg/ml and 121±29 dg/ml, p<0.001 for groups 2 and 1, respectively. The latter is most likely due to the fact that patients with CABG previously underwent PCI and lipid-lowering therapy was selected, but due to the fact that LDL-C remained above target values, destabilization and the need for subsequent revascularization occurred. But despite this, the inflammatory marker C-reactive protein (CRP) was elevated in patients with CABG (2.32 mg/l and 1.91 mg/l, p<0.005), indicating the presence of a chronic inflammatory process. Stroke was not assessed due to the small number of cases.