Antonio Jose V Vicente

Philippine Heart Center,
Philippines

Abstract Title: Association of Lipoprotein (a) with Severity of Coronary Arterial Lesions among Acute Coronary Syndrome Patients

Biography:

Antonio Jose V. Vicente, MD, obtained his medical degree from De La Salle Medical and Health Sciences Institute. He completed his residency training in Anatomic and Clinical Pathology at Philippine Heart Center, where he served as Chief Resident during his final year. He recently completed a research fellowship in cardiovascular pathology at the same institution.

Research Interest:

Background: Elevated lipoprotein(a) [Lp(a)] is an established, genetically determined risk factor for atherosclerotic cardiovascular disease. While its association with adverse cardiovascular events is well documented, its relationship with the angiographic severity and morphology of coronary lesions in acute coronary syndrome (ACS) remains unclear.

Objectives: To evaluate the association between serum Lp(a) and the severity and angiographic characteristics of coronary arterial lesions among study participants presenting with ACS.

Methods: This cross-sectional study included participants presenting with ACS. Serum Lp(a) levels were measured using a latex-enhanced immunoturbidimetric assay. Patients were stratified into high and low Lp(a) using the cutoff value of 300 mg/L. A subset of participants who underwent angiography was analyzed for angiographic features, including multivessel disease, left-main involvement, bifurcation, calcification, percent stenosis, and SYNTAX. Group comparisons and logistic regression analyses were performed to assess associations between elevated Lp(a) and angiographic severity.

Results: Among 87 patients with Lp(a) results, 81 underwent CA(coronary angiography). Elevated Lp(a) was not associated with multivessel disease, left main involvement, bifurcation, calcification, degree of stenosis, or SYNTAX scores. Trends toward a higher frequency of bifurcation, calcifications, and higher percent stenosis of the culprit vessel were observed in patients with elevated Lp(a), though these did not reach statistical significance. Smoking was significantly more common in the low Lp(a) group.

Conclusion: In the study participants presenting with ACS, elevated Lp(a) was not associated with overall angiographic severity or complexity. However, observed trends toward bifurcation involvement, calcification, and higher percent stenosis suggest a potential relationship between Lp(a) and plaque morphology rather than global disease burden. Baseline demographics were comparable, except for smoking, which was more common in the low Lp(a) group, highlighting the independence of Lp(a) from lifestyle risk factors